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Article
Novel Senescence Associated Gene, YPEL3, is Repressed by Estrogen in ER+ Mammary Tumor Cells and Required for Tamoxifen-Induced Cellular Senescence
International Journal of Cancer
  • Rebecca Tuttle, Wright State University
  • Kelly L. R. Miller, Wright State University
  • J. Nicholas Maiorano, Wright State University
  • Paula M. Termuhlen, Wright State University
  • Yongping Gao
  • Steven J. Berberich, Wright State University - Main Campus
Document Type
Article
Publication Date
5-15-2012
Abstract
Estrogen signaling plays an important role in breast carcinogenesis. An increased understanding of estrogen gene targets and their effects will allow for more directed and effective therapies for individuals with breast cancer, particularly those with estrogen receptor positive tumors resistant to tamoxifen therapy. Here, we identify YPEL3 as a growth suppressive protein downregulated by estrogen in estrogen receptor positive breast cancer cell lines. Estrogen repression of YPEL3 expression was found to be independent of p53 but dependent on estrogen receptor alpha expression. Importantly, YPEL3 expression, which is induced by the removal of estrogen or treatment with tamoxifen triggers cellular senescence in MCF-7 cells while loss of YPEL3 increases the growth rate of MCF-7 cells. Taken together these findings suggest that YPEL3 may represent a potential target for directed hormonal therapy for estrogen receptor positive breast cancer patients.
DOI
10.1002/ijc.26239
Citation Information
Rebecca Tuttle, Kelly L. R. Miller, J. Nicholas Maiorano, Paula M. Termuhlen, et al.. "Novel Senescence Associated Gene, YPEL3, is Repressed by Estrogen in ER+ Mammary Tumor Cells and Required for Tamoxifen-Induced Cellular Senescence" International Journal of Cancer Vol. 130 Iss. 10 (2012) p. 2291 - 2299 ISSN: 00207136
Available at: http://works.bepress.com/rebecca_tuttle/8/