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An Experimental Study of Effects of Overlaying Tissues on HIFU Lesion
Center for Nondestructive Evaluation Conference Papers, Posters and Presentations
  • Tao Long, Iowa State University
  • Viren R. Amin, Iowa State University
  • Ronald A. Roberts, Iowa State University
  • R. Bruce Thompson, Iowa State University
  • Scott R. McClure, Iowa State University
  • Timothy Ryken, University of Iowa
Document Type
Conference Proceeding
9th International Symposium on Therapeutic Ultrasound
Publication Date
(51.751724, -1.255285)

Understanding the effect of overlaying tissues on HIFU lesion is crucial for estimating HIFU dose distribution at a target tissue. We have run a series of experiments to systematically observe the effects of the overlaying tissues on the HIFU beam and ultimately the lesion created in the target tissue. First, we mapped out the HIFU transducer beam (in low power) under water without and with different overlaying tissue layers. Then, we performed a series of experiments in high power to create lesions in target tissues (e.g., liver) without and with overlaying tissues (e.g. muscle). The lesions are characterized by slicing the tissues and reconstructing the 3D lesion from calibrated pictures of the target tissue slices. The low power beam measurements show significant effects in terms of severe beam wave‐field amplitude distortion due to phase aberration introduced by velocity inhomogeneity in the overlaying tissues. These results compare well qualitatively with the computational models. The results from the high power HIFU lesions in a similar setup using various tissues, including liver and muscle, provide understanding of the significance of phase aberration in overlaying tissues and could prove useful towards high precision HIFU therapy.


Copyright 2007 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics.

The following article appeared in AIP Conference Proceedings 911 (2007): 237–241 which may be found at

Copyright Owner
American Institute of Physics
Citation Information
Tao Long, Viren R. Amin, Ronald A. Roberts, R. Bruce Thompson, et al.. "An Experimental Study of Effects of Overlaying Tissues on HIFU Lesion" Oxford, United Kingdom(2006)
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