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Article
Association of the 9p21.3 Locus With Risk of First-Ever Myocardial Infarction in Pakistanis
Arterioscler Thromb Vasc Biol.
  • Saleheen D, Center for Non-Communicable Diseases, Karachi
  • Myriam Alexander, Center for Non-Communicable Diseases, Karachi
  • Asif Rasheed, Center for Non-Communicable Diseases, Karachi
  • Rashid Jooma, Aga Khan University
Publication Date
7-1-2010
Document Type
Article
Disciplines
Abstract
Abstract OBJECTIVE: To examine variants at the 9p21 locus in a case-control study of acute myocardial infarction (MI) in Pakistanis and to perform an updated meta-analysis of published studies in people of European ancestry. METHODS AND RESULTS: A total of 1851 patients with first-ever confirmed MI and 1903 controls were genotyped for 89 tagging single-nucleotide polymorphisms at locus 9p21, including the lead variant (rs1333049) identified by the Wellcome Trust Case Control Consortium. Minor allele frequencies and extent of linkage disequilibrium observed in Pakistanis were broadly similar to those seen in Europeans. In the Pakistani study, 6 variants were associated with MI (P<10(-2)) in the initial sample set, and in an additional 741 cases and 674 controls in whom further genotyping was performed for these variants. For Pakistanis, the odds ratio for MI was 1.13 (95% CI, 1.05 to 1.22; P=2 x 10(-3)) for each copy of the C allele at rs1333049. In comparison, a meta-analysis of studies in Europeans yielded an odds ratio of 1.31 (95% CI, 1.26 to 1.37) for the same variant (P=1 x 10(-3) for heterogeneity). Meta-analyses of 23 variants, in up to 38,250 cases and 84,820 controls generally yielded higher values in Europeans than in Pakistanis. CONCLUSIONS: To our knowledge, this study provides the first demonstration that variants at the 9p21 locus are significantly associated with MI risk in Pakistanis. However, association signals at this locus were weaker in Pakistanis than those in European studies.
Citation Information
Saleheen D, Myriam Alexander, Asif Rasheed and Rashid Jooma. "Association of the 9p21.3 Locus With Risk of First-Ever Myocardial Infarction in Pakistanis" Arterioscler Thromb Vasc Biol. Vol. 30 Iss. 7 (2010) p. 1467 - 1473
Available at: http://works.bepress.com/rashid_jooma/95/