Skip to main content
Article
A novel microparticulate vaccine for melanoma cancer using transdermal delivery
Journal of microencapsulation
  • Tuhin Bhowmik
  • Bernadette D'Souza
  • Rangaiah Shashidharamurthy, Philadelphia College of Osteopathic Medicine
  • Carl Oettinger
  • Periasamy Selvaraj
  • Martin D'Souza
Document Type
Article
Publication Date
1-1-2011
Disciplines
Abstract
In this study, we formulated a microparticulate melanoma cancer vaccine via the transdermal route. The vaccine was delivered using microneedle-based Dermaroller® which is available for cosmetic purposes. Unlike subcutaneous injections, administration using microneedles is painless and in general can increase the permeability of many compounds ranging in size from small molecules to proteins and microparticles that do not normally penetrate the skin. The vaccine microparticles were taken up by the antigen presenting cells which demonstrated a strong IgG titre level of 930?ug/mL in serum samples. The formulation increased the immunogenicity of the vaccine by incorporating the antigen into an albumin matrix having a size range of around 0.63-1.4?μm which acted as a synthetic adjuvant. The animals were vaccinated with 1 prime and 4 booster doses administered every 14 days over 8 weeks duration, followed by challenge with live tumour cells which showed protection after transdermal vaccination. © 2011 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Comments

This article was published in Journal of microencapsulation, Volume 28, Issue 4, Pages 294-300.

The published version is available at http://dx.doi.org/10.3109/02652048.2011.559287.

Copyright © 2011 Informa.

Citation Information
Tuhin Bhowmik, Bernadette D'Souza, Rangaiah Shashidharamurthy, Carl Oettinger, et al.. "A novel microparticulate vaccine for melanoma cancer using transdermal delivery" Journal of microencapsulation Vol. 28 Iss. 4 (2011) p. 294 - 300
Available at: http://works.bepress.com/rangaiah_shashidharamurthy/19/