Article
Conjugate Addition of Indoles to α,β-Unsaturated Ketones Using Bismuth (III) Bromide
Green and Sustainable Chemistry
(2019)
Abstract
An efficient method for the conjugate addition of indoles to a variety of chalcones using BiBr3 in ethanol (190 proof) is reported. Products are isolated by a simple procedure that avoids an aqueous work up and extensive chromatography, thus minimizing waste. Bismuth (III) compounds are especially attractive from a green chemistry perspective because they are remarkably nontoxic, non-corrosive and relatively inexpensive.
Keywords
- Bismuth,
- Bismuth Bromide,
- Conjugate Addition,
- Green Chemistry,
- Indoles
Disciplines
Publication Date
July 18, 2019
Citation Information
Tyler J. Rauwolf, Zhijia Geng, Jared L. Renfroe, Jack H. Roireau, et al.. "Conjugate Addition of Indoles to α,β-Unsaturated Ketones Using Bismuth (III) Bromide" Green and Sustainable Chemistry Vol. 9 (2019) p. 79 - 84 Available at: http://works.bepress.com/ram_mohan/56/
Creative Commons license
This work is licensed under a Creative Commons CC_BY International License.