Article
Bismuth Compounds in Organic Synthesis: Synthesis of Dioxanes, Dioxepines, and Dioxolanes Catalyzed by Bismuth(III) Triflate
Synthesis
(2010)
Abstract
A simple method for the synthesis of l,3-dioxolanes from carbonyl compounds has been developed using l,2-bis(trimethylsilyloxy) ethane in the presence of bismuth (III) triflate as a catalyst. The bismuth(III) triflate catalyzed synthesis of a range of dioxanes and dioxepines has also been developed. In these latter cases, the carbonyl compound is treated with a diol, and triethyl orthoformate is used as a water scavenger. All these methods avoid the use of a Dean-Stark trap.
Keywords
- Aldehydes,
- ketones,
- protection,
- cyclic acetals,
- l,
- 2-bis(trimethylsilyloxy)ethane.
Disciplines
Publication Date
2010
Citation Information
Ram S. Mohan, Daniel M. Podgorski, Scott W. Krabbe, Long N. Le, et al.. "Bismuth Compounds in Organic Synthesis: Synthesis of Dioxanes, Dioxepines, and Dioxolanes Catalyzed by Bismuth(III) Triflate" Synthesis Iss. 16 (2010) Available at: http://works.bepress.com/ram_mohan/32/