The call of Christ, as He stated in Matthew 28:18-20, Mark 16:15, Luke 24:7-9, John 20:21 and Acts 1:8, is to be a continuous command to follow, in order to reach the different peoples group of the world including the urban professionals in North America metropolises. Based on surveys sent to Christian leaders in church congregations and professionals in the secular workplace along with the associated research in the subject, this thesis project reviews the Great Commission call to pursue urban professionals in metropolises, examining their lifestyle environment, past and current trends to reach them, biblical principles that can turn into methods to be used in their outreach and the practical implication analysis. The South Florida metropolises of Miami, Fort Lauderdale, and West Palm Beach are the pilot project location for this thesis work intended to be spread to other metropolises in North America and beyond.