Article
Use and Implications of the Harmonic Mean Model on Mixtures for Basic Research and Drug Discovery
ACS Combinatorial Science
Document Type
Article
Publication Date
3-11-2011
Keywords
- combinatorial libraries,
- drug discovery,
- harmonic mean model,
- mixture activity
Disciplines
Abstract
The use of the harmonic mean model for predicting the activities of a given mixture and its constituents has not previously been explored in the context of combinatorial libraries and drug discovery. Herein, the analyses of historical data confirm the harmonic mean as an accurate predictor of mixture activity. The implications of these results are discussed.
DOI
10.1021/co100065a
Citation Information
Radleigh Santos, Marc Giulianotti, Colette T. Dooley, Clemencia Pinilla, et al.. "Use and Implications of the Harmonic Mean Model on Mixtures for Basic Research and Drug Discovery" ACS Combinatorial Science Vol. 13 Iss. 3 (2011) p. 337 - 344 ISSN: 2156-8952 Available at: http://works.bepress.com/radleigh-santos/5/
Copyright © 2011 American Chemical Society