"Use and Implications of the Harmonic Mean Model on Mixtures for Basic Research and Drug Discovery" by Radleigh Santos

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Use and Implications of the Harmonic Mean Model on Mixtures for Basic Research and Drug Discovery

ACS Combinatorial Science

Radleigh Santos, Torrey Pines Institute for Molecular Studies
Marc Giulianotti, Torrey Pines Institute for Molecular Studies
Colette T. Dooley, Torrey Pines Institute for Molecular Studies
Clemencia Pinilla, Torrey Pines Institute for Molecular Studies
Jon R. Appel, Torrey Pines Institute for Molecular Studies
Richard A. Houghten, Torrey Pines Institute for Molecular Studies

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Document Type

Article

Publication Date

3-11-2011

Keywords

combinatorial libraries,
drug discovery,
harmonic mean model,
mixture activity

Disciplines

Abstract

The use of the harmonic mean model for predicting the activities of a given mixture and its constituents has not previously been explored in the context of combinatorial libraries and drug discovery. Herein, the analyses of historical data confirm the harmonic mean as an accurate predictor of mixture activity. The implications of these results are discussed.

Comments

DOI

10.1021/co100065a

Citation Information

Radleigh Santos, Marc Giulianotti, Colette T. Dooley, Clemencia Pinilla, et al.. "Use and Implications of the Harmonic Mean Model on Mixtures for Basic Research and Drug Discovery" ACS Combinatorial Science Vol. 13 Iss. 3 (2011) p. 337 - 344 ISSN: 2156-8952
Available at: http://works.bepress.com/radleigh-santos/5/