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Contribution to Book
Sex Differences in Chronic Stress: Role of Estradiol in Cognitive Resilience
Psychology Faculty Publications
  • Victoria N. Luine, CUNY Hunter College
  • Juan Gomez, National Institute on Drug Abuse
  • Kevin D. Beck, New Jersey Medical School
  • Rachel E. Bowman, Sacred Heart University
Document Type
Book Chapter
Publication Date

Stress is associated with psychiatric disorders which show sex differences in expression. Application of chronic stressors to rodents has been used as a model for understanding the bases of these sex differences and for developing new treatments. Female rats are more resilient than males to chronic restraint stress in the cognitive domain, and estradiol, of both ovarian and neural origin, contributes to this resilience. For anxiety, chronic stress appears anxiogenic in both sexes, and limited information suggests that estradiol does not alter anxiety responses to stress. Depression in males is enhanced following different chronic stressors, but a lack of studies in females limits determining whether females are more resilient or susceptible to stress-dependent depression. These findings are presented and discussed within the framework of making the animal models more consistent with the behavioral phenotype of human females and for improving future research.

Citation Information

Luine, V., Gomez, J., Beck, K., Bowman, R. (2017). Sex differences in chronic stress: Role of estradiol in cognitive resilience. In G. Fink (Ed.). Stress: Neuroendocrinology and Neurobiology (pp. 317-325). (Handbook of Stress Series, Volume 2). London: Academic Press. doi:10.1016/B978-0-12-802175-0.00032-2