This article focuses on the self-efficacy and intercultural adaptation of Chinese Students at several U.S. universities. The increasing number of Chinese students at U.S. universities is accompanied by a burgeoning literature on intercultural adaptation and crosscultural adjustment of these Chinese students. Past research shows that Asian students usually encounter far greater difficulties than do other international students in their adaptation to U.S. host culture. The influence of general, social and academic self-efficacy on the psychological, sociocultural and academic adaptation of Chinese students is investigated. This study is unique in that it explores the relationships of three facets of self-efficacy with three dimensions of intercultural adaptation.