Article
Synergistic Effects of Anti-CmeA and Anti-CmeB Peptide Nucleic Acids on Sensitizing Campylobacter jejuni to Antibiotics
Antimicrobial Agents and Chemotherapy
Document Type
Article
Disciplines
Publication Version
Published Version
Publication Date
9-1-2013
DOI
10.1128/AAC.00605-13
Abstract
The CmeABC efflux pump in Campylobacter jejuni confers resistance to structurally divergent antimicrobials, and inhibition of CmeABC represents a promising strategy to control antibiotic-resistant Campylobacter. Antisense peptide nucleic acids (PNAs) targeting the three components of CmeABC were evaluated for inhibition of CmeABC expression. The result revealed a synergistic effect of the PNAs targeting CmeA and CmeB on sensitizing C. jejuni to antibiotics. This finding further demonstrates the feasibility of using PNAs to potentiate antibiotics against antibiotic-resistant Campylobacter.
Copyright Owner
American Society for Microbiology
Copyright Date
2013
Language
en
File Format
application/pdf
Citation Information
Yang Mu, Zhangqi Shen, Byeonghwa Jeon, Lei Dai, et al.. "Synergistic Effects of Anti-CmeA and Anti-CmeB Peptide Nucleic Acids on Sensitizing Campylobacter jejuni to Antibiotics" Antimicrobial Agents and Chemotherapy Vol. 57 Iss. 9 (2013) p. 4575 - 4577 Available at: http://works.bepress.com/qijing-zhang/29/
This article is published as Mu, Yang, Zhangqi Shen, Byeonghwa Jeon, Lei Dai, and Qijing Zhang. "Synergistic effects of anti-CmeA and anti-CmeB peptide nucleic acids on sensitizing Campylobacter jejuni to antibiotics." Antimicrobial agents and chemotherapy 57, no. 9 (2013): 4575-4577. doi: 10.1128/AAC.00605-13. Posted with permission.