Skip to main content
Other
Combinational Effects of Apocynin and Mitoquinone in Reducing Myocardial Ischemia/reperfusion (MI/R) Injury
Research Day
  • William Chau, Philadelphia College of Osteopathic Medicine
  • Regina Ondrasik, Philadelphia College of Osteopathic Medicine
  • H. Patel, Philadelphia College of Osteopathic Medicine
  • Issachar Devine, Philadelphia College of Osteopathic Medicine
  • Matthew Lepera, Philadelphia College of Osteopathic Medicine
  • Qian Chen, Philadelphia College of Osteopathic Medicine
  • Robert J. Barsotti, Philadelphia College of Osteopathic Medicine
  • Lindon H. Young, Philadelphia College of Osteopathic Medicine
Location
Philadelphia Camppus
Start Date
7-5-2014 1:00 PM
Description

Reactive oxygen species (ROS) is generated due to the influx of oxygen during MI/R and contributes to post-reperfused cardiac contractile dysfunction and increased infarct size. Damaged mitochondria and NADPH oxidase activation are major sites of ROS in MI/R. In prior studies, apo, a NADPH oxidase inhibitor, and mitoQ, a mitochondrial-targeted antioxidant, dose-dependently improved post-reperfused left ventricular developed pressure (LVDP) and reduced infarct size in rat hearts subjected to I(30min)/R(45min). This led us to question whether low doses of apo and mitoQ given together can act synergistically to improve post-reperfused LVDP and reduce infarct size compared to either drug alone or control? Early data shows that the combination of apo (40μM) + mitoQ (1 μM ) (n=7) reduced infarct size to 27 ± 11% compared to mitoQ (1 μM) (n= 6) 54 ± 6% (p

Citation Information
William Chau, Regina Ondrasik, H. Patel, Issachar Devine, et al.. "Combinational Effects of Apocynin and Mitoquinone in Reducing Myocardial Ischemia/reperfusion (MI/R) Injury" (2014)
Available at: http://works.bepress.com/qian_chen/23/