|Present||Assistant Professor of Physiology and Pharmacology, Philadelphia College of Osteopathic Medicine ‐ Department of Bio-Medical Sciences|
|2012 - 2015||Evaluation of tetrahydrobiopterin/dihydrobiopterin ratio in vascular injury tissues|
|Pennsylvania State Tobacco Grant - 4100057680|
|2013 - 2014||The role of mitochondria in acute hyperglycemia: activation of vascular NADPH oxidase and eNOS uncoupling|
|Center for Chronic Disorders of Aging (CCDA) at PCOM|
Professional Service and Affiliations
|2013 - Present||Member, American Heart Association||2011 - Present||Member, American Peptide Society||2007 - Present||Member, Sigma Xi Society||2005 - 2014||Member, Neuroscience Society||Reviewer, Evidence-Based Complementary and Alternative Medicine|
|2001||MD/PhD, Xi'an Jiao Tong University School of Medicine|
|1998||MS, Xi'an Medical University|
|1995||BS, Xi'an Medical University|
Scholarly Articles (27)
Mitochondrial targeted antioxidants, mitoquinone and SKQ1, not vitamin C, mitigate ...
BMC Pharmacology & Toxicology (2021)
BACKGROUND: Preconditioning of the heart ameliorates doxorubicin (Dox)-induced cardiotoxicity. We tested whether pretreating cardiomyocytes by mitochondrial-targeted antioxidants, mitoquinone (MitoQ) or ...
Apocynin Exerts Dose-Dependent Cardioprotective Effects by Attenuating Reactive Oxygen Species ...
Cardiovascular Pharmacology (2016)
Ischemia/reperfusion results in cardiac contractile dysfunction and cell death partly due to increased reactive oxygen species and decreased endothelial-derived nitric ...
Inhibition of Long Chain Fatty Ccyl-CoA Synthetase (ACSL) and Ischemia ...
Bioorganic & Medicinal Chemistry Letters (2014)
Various triacsin C analogs, containing different alkenyl chains and carboxylic acid bioisoteres including 4-aminobenzoic acid, isothiazolidine dioxide, hydroxylamine, hydroxytriazene, and ...
The Role of Tetrahydrobiopterin and Dihydrobiopterin in Ischemia/Reperfusion Injury ...
Advances in Pharmacological Sciences (2010)
Reduced nitric oxide (NO) bioavailability and increased oxidative stress are major factors mediating ischemia/reperfusion (I/R) injury. Tetrahydrobiopterin (BH(4)) is an ...
Mechanisms Related to the Cardioprotective Effects of Protein Kinase C ...
Naunyn-Schmiedebergs Archives of Pharmacology (2008)
The role of protein kinase C epsilon (PKC epsilon) in polymorphonuclear leukocyte (PMN)-induced myocardial ischemia/reperfusion (MI/R) injury and novel-related mechanisms, ...
Presynaptic a1 adrenergic receptors differentially regulate synaptic glutamate and GABA ...
Journal of Pharmacology and Experimental Therapeutics (2006)
The hypothalamic paraventricular nucleus (PVN) neurons that project to the spinal intermediolateral cell column and brainstem are important for the ...