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Article
Efficacy and Safety of a Modular Multi-modal Exercise Program in Prostate Cancer Patients with Bone Metastases: A Randomized Controlled Trial
ECU Publications 2011
  • Daniel Galvao, Edith Cowan University
  • Dennis R. Taaffe
  • Prue Cormie, Edith Cowan University
  • Nigel Spry
  • Susan K. Chambers
  • Carolyn Peddle-McIntyre, Edith Cowan University
  • Michael Baker, Edith Cowan University
  • James Denham
  • David Joseph
  • Geoff Groom
  • Robert Newton, Edith Cowan University
Publication Date
1-1-2011
Document Type
Journal Article
Publisher
BioMed Central
Faculty
Faculty of Computing, Health and Science
School
ECU Health and Wellness Institute
RAS ID
13188
Comments

This article was originally published as: Galvao, D. A., Taaffe, D.R., Cormie, P. , Spry, N., Chambers, S.K., Peddle-McIntyre, C., Baker, M. , Denham, J., Joseph, D., Groom, G., & Newton, R.U. (2011). Efficacy and safety of a modular multi-modal exercise program in prostate cancer patients with bone metastases: A randomized controlled trial. BMC Cancer, 11, Article Number 517. Original article available here

Abstract

Background: The presence of bone metastases has excluded participation of prostate cancer patients in exercise intervention studies to date and is also a relative contraindication to supervised exercise in the community setting because of concerns of fragility fracture. However, this group of patients often have developed significant muscle atrophy and functional impairments from prior and continuing androgen deprivation that is exacerbated by subsequent and more intensive interventions such as chemotherapy. The aim of this study is to determine the efficacy and safety of a modular multi-modal exercise program in prostate cancer patients with bone metastases. Methods/Design: Multi-site randomized controlled trial in Western Australia and New South Wales to examine the efficacy and safety of a modular multi-modal physical exercise program in 90 prostate cancer survivors with bone metastases. Participants will be randomized to (1) modular multi-modal exercise intervention group or (2) usual medical care group. The modular multi-modal exercise group will receive a 3-month supervised exercise program based on bone lesion location/extent. Measurements for primary and secondary endpoints will take place at baseline, 3 months (end of the intervention) and 6 months follow-up. Discussion: Delaying or preventing skeletal complication and improving physical function for men with bone metastases would provide clinically meaningful benefits to patients. However, exercise programs must be designed and executed with careful consideration of the skeletal complications associated with bone metastatic disease and cumulative toxicities from androgen deprivation such as osteoporosis and increased risk of fractures. The results from this study will form the basis for the development of a specific exercise prescription in this patient group in order to alleviate disease burden, counteract the adverse treatment related side-effects and enhance quality of life. Trial Registration: ACTRN: ACTRN12611001158954

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Creative Commons License
Creative Commons Attribution 2.0
Citation Information
Daniel Galvao, Dennis R. Taaffe, Prue Cormie, Nigel Spry, et al.. "Efficacy and Safety of a Modular Multi-modal Exercise Program in Prostate Cancer Patients with Bone Metastases: A Randomized Controlled Trial" (2011)
Available at: http://works.bepress.com/prue_cormie/12/