This paper presents a novel interleaved high-gain DC-DC boost converter with Greinacher voltage multiplier cells (GVMC). The proposed topology consists of two stages: an interleaved boost stage to reduce the AC ripple on the input current and the voltage multiplier circuit to increase the voltage gain ratio. The voltage stress on active switches is lower than that from the conventional boost converter, which allows selection of efficient components. The interleaved boost stage contains two inductors and two switches with the capability of being fed by either a single or two sources. Steady-state analysis and design of active and passive components are illustrated. A 20 to a 400 Vdc converter model is simulated, and A 200 W, prototype is experimentally implemented to verify the theory and simulation.