Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variationsFaculty of Science - Papers (Archive)
AbstractThe facile synthesis of seven new dicationic tripeptide benzyl ester derivatives, with hydrophobic group variations in the C-terminal amino acid component, is described. Moderate to good activity was seen against Gram-positive bacteria in vitro. One cyclohexyl-substituted compound 2c was tested more widely and showed good potency (MIC values ranging from 2–4 μg/mL) against antibiotic-resistant strains of Staphylococcus aureus and Enterococci (VRE, VSE), and against Staphylococcus epidermidis.
Citation InformationJohn Bremner, Paul A. Keller, Stephen Pyne, Mark Robertson, et al.. "Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations" (2012) p. 1265 - 1270
Available at: http://works.bepress.com/pkeller/49/