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Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations
Faculty of Science - Papers (Archive)
  • John Bremner, University of Wollongong
  • Paul A. Keller, University of Wollongong
  • Stephen Pyne, University of Wollongong
  • Mark Robertson, University of Wollongong
  • Kandasamy Sakthivel, University of Wollongong
  • Kittiya Somphol, University of Wollongong
  • Dean Baylis, Avexa Ltd
  • Jonathon A Coates, Avexa Ltd
  • John Deadman, Chemocopeia Pty Ltd, Vic
  • Dharshini Jeevarajah, Avexa Ltd
  • David I Rhodes, JDJ Bioservices
RIS ID
63630
Publication Date
1-1-2012
Publication Details

Bremner, J., Keller, P., Pyne, S., Robertson, M., Sakthivel, K., Somphol, K., Baylis, D., Coates, J., Deadman, J., Jeevarajah, D., Rhodes, D. (2012). Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations. Beilstein Journal of Organic Chemistry, 8 1265-1270.

Abstract
The facile synthesis of seven new dicationic tripeptide benzyl ester derivatives, with hydrophobic group variations in the C-terminal amino acid component, is described. Moderate to good activity was seen against Gram-positive bacteria in vitro. One cyclohexyl-substituted compound 2c was tested more widely and showed good potency (MIC values ranging from 2–4 μg/mL) against antibiotic-resistant strains of Staphylococcus aureus and Enterococci (VRE, VSE), and against Staphylococcus epidermidis.
Citation Information
John Bremner, Paul A. Keller, Stephen Pyne, Mark Robertson, et al.. "Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations" (2012) p. 1265 - 1270
Available at: http://works.bepress.com/pkeller/49/