Synthesis and antibacterial activity of C2-symmetric binaphthyl scaffolded amino acid derivativesFaculty of Science - Papers (Archive)
AbstractThe synthesis of eleven novel antibacterial agents is reported. The structures are based on a C2-symmetric binaphthyl scaffold which holds two identical chains consisting of a short linker, a basic amino acid and a small hydrophobic side chain. Antibacterial activity is revealed for a number of derivatives down to an MIC of 2 μg/mL (2 μM) against Staphylococcus aureus - comparable to vancomycin, and an MIC of 31 μg/mL (31 μM) against some vancomycin-resistant enterococcal strains. 2011 Elsevier Masson SAS. All rights reserved.
Citation InformationM Robertson, John B Bremner, J Coates, John Deadman, et al.. "Synthesis and antibacterial activity of C2-symmetric binaphthyl scaffolded amino acid derivatives" (2011) p. 4201 - 4211
Available at: http://works.bepress.com/pkeller/42/