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Synthesis and antibacterial activity of C2-symmetric binaphthyl scaffolded amino acid derivatives
Faculty of Science - Papers (Archive)
  • M Robertson
  • John B Bremner, University of Wollongong
  • J Coates
  • John Deadman
  • Paul A Keller, University of Wollongong
  • Stephen G Pyne, University of Wollongong
  • Kittiya Somphol
  • David I Rhodes, Avexa Ltd
RIS ID
38589
Publication Date
1-1-2011
Publication Details

Robertson, M., Bremner, J. B., Coates, J., Deadman, J., Keller, P. A., Pyne, S. G., Somphol, K. and Rhodes, D. I. (2011). Synthesis and antibacterial activity of C2-symmetric binaphthyl scaffolded amino acid derivatives. European Journal of Medicinal Chemistry, 46 (9), 4201-4211.

Abstract
The synthesis of eleven novel antibacterial agents is reported. The structures are based on a C2-symmetric binaphthyl scaffold which holds two identical chains consisting of a short linker, a basic amino acid and a small hydrophobic side chain. Antibacterial activity is revealed for a number of derivatives down to an MIC of 2 μg/mL (2 μM) against Staphylococcus aureus - comparable to vancomycin, and an MIC of 31 μg/mL (31 μM) against some vancomycin-resistant enterococcal strains. 2011 Elsevier Masson SAS. All rights reserved.
Citation Information
M Robertson, John B Bremner, J Coates, John Deadman, et al.. "Synthesis and antibacterial activity of C2-symmetric binaphthyl scaffolded amino acid derivatives" (2011) p. 4201 - 4211
Available at: http://works.bepress.com/pkeller/42/