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Article
Recent Applications of Chemical Imaging to Pharmaceutical Process Monitoring and Quality Control
Articles
  • A. A. Gowen, University College Dublin
  • Colm O'Donnell, Dublin Institute of Technology
  • Patrick Cullen, Dublin Institute of Technology
  • S. Bell, Quens University, Belfast
Document Type
Article
Publication Date
2008-5-1
Rights
This item is available under a Creative Commons License for non-commercial use only
Disciplines
Publication Details

Published in European Journal of Pharmaceutics and Biopharmaceutics, 2008, Vol. 69 (1), pp.10-22. Available here

doi:10.1016/j.ejpb.2007.10.013

Abstract
Chemical Imaging (CI) is an emerging platform technology that integrates conventional imaging and spectroscopy to attain both spatial and spectral information from an object. Vibrational spectroscopic methods, such as Near Infrared (NIR) and Raman spectroscopy, combined with imaging are particularly useful for analysis of biological/pharmaceutical forms. The rapid, non-destructive and non-invasive features of CI mark its potential suitability as a process analytical tool for the pharmaceutical industry, for both process monitoring and quality control in the many stages of drug production. This paper provides an overview of CI principles, instrumentation and analysis. Recent applications of Raman and NIR-CI to pharmaceutical quality and process control are presented; challenges facing CI implementation and likely future developments in the technology are also discussed.
DOI
10.1016/j.ejpb.2007.10.013
Citation Information
Gowen, A.A. et al (2008) Recent applications of chemical imaging to pharmaceutical process monitoring and quality control. European Journal of Pharmaceutics and Biopharmaceutics, 2008, Vol. 69 (1), pp.10-22.