The temporal and spatial scales controlling the morphodynamics of barrier-inlet systems are critical components of regional sediment management practice. This paper discusses regional sediment management methods employed at multiple barrier-inlet systems, with case studies from West-Central Florida. A decision-support tool is proposed for regional sediment management with discussion of its application to barrier-inlet systems. Connecting multiple barrier islands and inlets at appropriate spatio-temporal scales is critical in developing an appropriately scoped sediment management plan for a barrier-inlet system. Evaluating sediment bypassing capacity and overall inlet morphodynamics can better inform regional sand sharing along barrier-inlet coastlines; particularly where sediment resources are scarce and a close coupling between inlet dredging and beach placement is vital to long-term sustainable management. Continued sea-level rise and anthropogenic activities may intensify the need for investigating longer-term processes and expanding regional planning at a centennial timescale, and are acknowledged as challenging tasks for RSM studies. Specifically, we suggested that a regionally focused, multi-inlet study were necessary for management plan of individual inlet for the west-central Florida case studies. Key recommendations based on the case studies include: 1) allow the natural sediment bypassing to be re-established at Blind Pass inlet through reduced ebb-tidal delta mining, 2) reduce the interruption to sediment bypassing at John's Pass and Pass-a-Grille inlets through an improved design of the dredged mining areas located along sediment bypassing pathways, 3) allow for continued natural sediment bypassing at Bunces Pass, and, 4) incorporate the cyclic swash-bar attachment sediment bypassing into the management plan at Bunces Pass and adjacent barrier-islands.