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Article
Human-Specific Loss of Regulatory DNA and the Evolution of Human-Specific Traits
Nature
  • Cory Y McLean
  • Philip L Reno, Philadelphia College of Osteopathic Medicine
  • Alex A Pollen
  • Abraham I Bassan
  • Terence D Capellini
  • Catherine Guenther
  • Vahan B Indjeian
  • Xinhong Lim
  • Douglas B Menke
  • Bruce T Schaar
  • Aaron M Wenger
  • Gill Bejerano
  • David M Kingsley
Document Type
Article
Publication Date
3-10-2011
Abstract
Humans differ from other animals in many aspects of anatomy, physiology, and behaviour; however, the genotypic basis of most human-specific traits remains unknown. Recent whole-genome comparisons have made it possible to identify genes with elevated rates of amino acid change or divergent expression in humans, and non-coding sequences with accelerated base pair changes. Regulatory alterations may be particularly likely to produce phenotypic effects while preserving viability, and are known to underlie interesting evolutionary differences in other species. Here we identify molecular events particularly likely to produce significant regulatory changes in humans: complete deletion of sequences otherwise highly conserved between chimpanzees and other mammals. We confirm 510 such deletions in humans, which fall almost exclusively in non-coding regions and are enriched near genes involved in steroid hormone signalling and neural function. One deletion removes a sensory vibrissae and penile spine enhancer from the human androgen receptor (AR) gene, a molecular change correlated with anatomical loss of androgen-dependent sensory vibrissae and penile spines in the human lineage. Another deletion removes a forebrain subventricular zone enhancer near the tumour suppressor gene growth arrest and DNA-damage-inducible, gamma (GADD45G), a loss correlated with expansion of specific brain regions in humans. Deletions of tissue-specific enhancers may thus accompany both loss and gain traits in the human lineage, and provide specific examples of the kinds of regulatory alterations and inactivation events long proposed to have an important role in human evolutionary divergence.
PubMed ID
21390129
Comments

This article was published in Nature, Volume 471, Issue 7337, Pages 216-219.

The published version is available at http://dx.doi.org/10.1038/nature09774.

Copyright © 2011.

Citation Information
Cory Y McLean, Philip L Reno, Alex A Pollen, Abraham I Bassan, et al.. "Human-Specific Loss of Regulatory DNA and the Evolution of Human-Specific Traits" Nature Vol. 471 Iss. 7337 (2011) p. 216 - 219
Available at: http://works.bepress.com/philip-reno/18/