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Presentation
595 Improved Patient-Reported Outcomes in Psoriatic Arthritis Patients Treated with Abatacept: Results from a Phase III Trial. American College of Rheumatology (ACR) Annual Meeting, San Diego CA, Nov. 2017. Arthritis Rheumatol 2017.
American College of Rheumatology (ACR) Annual Meeting (2017)
  • Philip Mease, Providence St. Joseph Health
  • V Strand
  • T Alemao
  • T Lehman
  • S. Banerjee
  • HA Ahmad
Abstract
Background/Purpose: In the Phase III ASTRAEA study (NCT01860976), abatacept (ABA) significantly increased ACR20 responses, alleviating musculoskeletal symptoms in patients (pts) with active psoriatic arthritis (PsA).1 Here we explore the effect of ABA on pt-reported outcomes (PROs) in ASTRAEA. Methods: Pts were randomized (1:1) to SC ABA 125 mg weekly or placebo (PBO) for 24 weeks (W). At W16, pts without ≥20% improvement in joint counts escaped to open-label ABA. Adjusted mean changes from baseline to W16 (all pts) and W24 (non-escape responder analysis) in Short Form-36 (SF-36; physical and mental component summary [PCS, MCS] and individual domain scores using spydergrams), HAQ-DI, Dermatology QoL Index (DLQI), and Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scores were evaluated in total population (prespecified intent-to-treat analysis) and subgroups (post hoc) stratified by baseline CRP and prior TNF inhibitor (TNFi) use. Proportions of pts reporting improvements from baseline ≥minimal clinically important difference (MCID) in SF-36 summary (≥2.5) and domains (≥5.0), FACIT-F (≤−4.0), and HAQ-DI (≤–0.35), and scores ≥normative values in SF-36 summary (≥50) and individual domains, FACIT-F (<40), and HAQ-DI (<0.5) at W16 were analyzed in the total population. Results: 
Disciplines
Publication Date
September, 2017
Citation Information
Philip Mease, V Strand, T Alemao, T Lehman, et al.. "595 Improved Patient-Reported Outcomes in Psoriatic Arthritis Patients Treated with Abatacept: Results from a Phase III Trial. American College of Rheumatology (ACR) Annual Meeting, San Diego CA, Nov. 2017. Arthritis Rheumatol 2017." American College of Rheumatology (ACR) Annual Meeting (2017)
Available at: http://works.bepress.com/philip-mease/164/