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Unpublished Paper
Profile likelihood confidence intervals for ECx
Statistics Technical Reports
Document Type
Report
Publication Date
1-20-2020
Disciplines
Abstract
Confidence intervals for effective concentrations (EC's) are commonly computed in dose response curve analyse. Profile intervals offer an alternative method for computing the confidence intervals in situations where delta method based confidence intervals produce intervals with values outside of a practical range. In this document, we describe the computation of profile intervals for EC's. We then introduce an R function, profile.ECx(), for computing these intervals from a dose response model fit by the drm() function in the drc package. Supplemental material includes three files of R code that define profile.ECx() and its helper functions and R code and data for the two examples.
Copyright Owner
The Authors
Copyright Date
2020
Language
en
File Format
application/pdf
Citation Information
Philip M. Dixon, Katherine J. Goode and C. Lay. "Profile likelihood confidence intervals for ECx" (2020) Available at: http://works.bepress.com/philip-dixon/74/
See the attached supplemental files below.