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Paradoxical Results of Adaptive False Discovery Rate Procedures in Neuroimaging Studies
NeuroImage (2012)
  • Philip T. Reiss
  • Armin Schwartzman, Harvard University
  • Feihan Lu
  • Lei Huang, Johns Hopkins University
  • Erika Proal
Abstract

Adaptive false discovery rate (FDR) procedures, which offer greater power than the original FDR procedure of Benjamini and Hochberg, are often applied to statistical maps of the brain. When a large proportion of the null hypotheses are false, as in the case of widespread effects such as cortical thinning throughout much of the brain, adaptive FDR methods can surprisingly reject more null hypotheses than not accounting for multiple testing at all—i.e., using uncorrected p-values. A straightforward mathematical argument is presented to explain why this can occur with the q-value method of Storey and colleagues, and a simulation study shows that it can also occur, to a lesser extent, with a two-stage FDR procedure due to Benjamini and colleagues. We demonstrate the phenomenon with reference to a published data set documenting cortical thinning in attention deficit/hyperactivity disorder. The paper concludes with recommendations for how to proceed when adaptive FDR results of this kind are encountered in practice.

Keywords
  • adjusted p-values,
  • attention deficit/hyperactivity disorder,
  • cortical thickness,
  • false discovery rate,
  • multiple testing,
  • q-values
Publication Date
December, 2012
Citation Information
Philip T. Reiss, Armin Schwartzman, Feihan Lu, Lei Huang, et al.. "Paradoxical Results of Adaptive False Discovery Rate Procedures in Neuroimaging Studies" NeuroImage Vol. 63 Iss. 4 (2012)
Available at: http://works.bepress.com/phil_reiss/26/