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Extracting Information from Functional Connectivity Maps via Function-on-Scalar Regression
NeuroImage (2011)
  • Philip T. Reiss, New York University
  • Maarten Mennes, New York University
  • Eva Petkova, New York University
  • Lei Huang, New York University
  • Matthew J. Hoptman
  • Bharat B. Biswal, University of Medicine and Dentistry of New Jersey
  • Stanley J. Colcombe
  • Xi-Nian Zuo, New York University
  • Michael P. Milham, New York University
Abstract

Functional connectivity of an individual human brain is often studied by acquiring a resting state functional magnetic resonance imaging scan, and mapping the correlation of each voxel's BOLD time series with that of a seed region. As large collections of such maps become available, including multisite data sets, there is an increasing need for ways to distill the information in these maps in a readily visualized form. Here we propose a two-step analytic strategy. First, we construct connectivity-distance profiles, which summarize the connectivity of each voxel in the brain as a function of distance from the seed, a functional relationship that has attracted much recent interest. Next, these profile functions are regressed on predictors of interest, whether categorical (e.g., acquisition site or diagnostic group) or continuous (e.g., age). This procedure can provide insight into the roles of multiple sources of variation, and detect large-scale patterns not easily available from conventional analyses. We illustrate the proposed methods with a resting state data set pooled across four imaging sites.

Keywords
  • functional connectivity,
  • functional data analysis,
  • model selection,
  • quantile regression,
  • resting state,
  • seed region
Publication Date
2011
Citation Information
Philip T. Reiss, Maarten Mennes, Eva Petkova, Lei Huang, et al.. "Extracting Information from Functional Connectivity Maps via Function-on-Scalar Regression" NeuroImage Vol. 56 Iss. 1 (2011)
Available at: http://works.bepress.com/phil_reiss/18/