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Article
Effects of a novel chitosan gel on mucosal wound healing following endoscopic sinus surgery in a sheep model of chronic rhinosinusitis.
The Laryngoscope (2008)
  • T Athanasiadis
  • A Beule
  • B Robinson
  • S Robinson
  • Z Shi
  • Peter-John Wormald
Abstract
Introduction: Postoperative bleeding and adhesion formation remain the two major problems after endoscopic sinus surgery (ESS). This study investigates the effect on adhesion formation and wound healing in a sheep model of chronic sinusitis of three topical agents: recombinant tissue factor (rTF, Dade Innovin, Marburg, Germany), poly-ethylene glycol (SprayGel, Confluent Surgical, Waltham, MA), and a novel chitosan-dextran derivative gel (CD, Department of Chemistry, University of Otago, Dunedin, New Zealand).
Keywords
  • endoscopic sinus surgery,
  • adhesion barrier,
  • chitosan,
  • dextran,
  • wound healing gel,
  • SprayGel,
  • polyethylene,
  • tissue factor,
  • sheep,
  • chronic rhinosinusitis,
  • sealant
Publication Date
2008
Citation Information
T Athanasiadis, A Beule, B Robinson, S Robinson, et al.. "Effects of a novel chitosan gel on mucosal wound healing following endoscopic sinus surgery in a sheep model of chronic rhinosinusitis." The Laryngoscope Vol. 118 (2008)
Available at: http://works.bepress.com/peterj_wormald/8/