The past decade has seen investment law entering the intellectual property domain. Welcome or not, this area of law has raised questions and concerns about the future of the international intellectual property regime. This chapter explores the changing chemistry between intellectual property and investment law. Specifically, it discusses future developments in four areas: (1) international trade and investment agreements; (2) investor-state disputes involving intellectual property claims; (3) new developments in intellectual property law; and (4) external considerations outside the intellectual property and investment domains.