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Article
Ruminal Fermentation of Propylene Glycol and Glycerol
Journal of Agricultural and Food Chemistry
  • Steven Trabue, United States Department of Agriculture
  • Kenwood Scoggin, United States Department of Agriculture
  • Siska Tjandrakusuma, Iowa State University
  • Mark A. Rasmussen, United States Department of Agriculture
  • Peter J. Reilly, Iowa State University
Document Type
Article
Publication Date
7-27-2007
DOI
10.1021/jf071076i
Abstract
Bovine rumen fluid was fermented anaerobically with 25 mM R-propylene glycol, S-propylene glycol, or glycerol added. After 24 h, all of the propylene glycol enantiomers and approximately 80% of the glycerol were metabolized. Acetate, propionate, butyrate, valerate, and caproate concentrations, in decreasing order, all increased with incubation time. Addition of any of the three substrates somewhat decreased acetate formation, while addition of either propylene glycol increased propionate formation but decreased that of butyrate. R- and S-propylene glycol did not differ significantly in either their rates of disappearance or the products formed when they were added to the fermentation medium. Fermentations of rumen fluid containing propylene glycol emitted the sulfur-containing gases 1-propanethiol, 1-(methylthio)propane, methylthiirane, 2,4-dimethylthiophene, 1-(methylthio)-1-propanethiol, dipropyl disulfide, 1-(propylthio)-1-propanethiol, dipropyl trisulfide, 3,5-diethyl-1,2,4-trithiolane, 2-ethyl-1,3-dithiane, and 2,4,6-triethyl-1,3,5-trithiane. Metabolic pathways that yield each of these gases are proposed. The sulfur-containing gases produced during propylene glycol fermentation in the rumen may contribute to the toxic effects seen in cattle when high doses are administered for therapeutic purposes.
Comments

Posted with permission from Journal of Agricultural and Food Chemistry, 55, no. 17 (2007): 7043–7051, doi:10.1021/jf071076i. Copyright 2007 American Chemical Society.

Copyright Owner
American Chemical Society
Language
en
File Format
application/pdf
Citation Information
Steven Trabue, Kenwood Scoggin, Siska Tjandrakusuma, Mark A. Rasmussen, et al.. "Ruminal Fermentation of Propylene Glycol and Glycerol" Journal of Agricultural and Food Chemistry Vol. 55 Iss. 17 (2007) p. 7043 - 7051
Available at: http://works.bepress.com/peter_reilly/25/