Carboxypeptidase O (CPO) is a protease that cuts acidic amino acids from the carboxyl terminus of a substrate protein. Besides its potential digestive application, not much else is known about its other activities in the body. This study aims to describe the expression pattern of CPO using the thirteen-lined ground squirrel as a model mammalian system. Thus far we have sampled tissue from one ground squirrel and analyzed those samples via Western blot. Immunoreactive bands likely to be CPO (molecular weight approximately 42 kDa) were seen in kidney, liver, and small intestine tissue samples. Further investigation will include immunohistochemical analysis.
Available at: http://works.bepress.com/peter_lyons/5/