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Diabetes and Breast Cancer among Women with BRCA1 and BRCA2 Mutations
  • Louise Bordeleau, Juravinski Cancer Centre, Hamilton, ON
  • Lorraine Lipscombe, Women's College Hospital, Toronto, ON
  • Jan Lubinski, Pomeranian Medical University, Szczecin, Poland
  • Parviz Ghadirian, University of Montreal
  • William D. Foulkes, McGill University
  • Susan Neuhausen, City of Hope National Medical Center, Duarte, CA
  • Peter Ainsworth, The University of Western Ontario
  • Michael Pollak, McGill University
  • Ping Sun, Women's College Hospital, Toronto, ON
  • Steven A. Narod, Women's College Hospital, Toronto, ON
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BACKGROUND:: Hyperinsulinemia and the metabolic syndrome are both risk factors for breast cancer. It is not clear if diabetes is associated with the risk of breast cancer in women with a BRCA1 or BRCA2 mutation. METHODS:: The authors reviewed the medical histories of 6052 women with a BRCA1 or BRCA2 mutation, half of whom had been diagnosed with breast cancer. They estimated the odds ratio for breast cancer, given a self-report of diabetes. They then estimated the hazard ratio for a new diagnosis of diabetes associated with a history of breast cancer. RESULTS:: There was no excess of diabetes in the period before the diagnosis of breast cancer, compared with controls with no diagnosis of breast cancer. The risk of diabetes was doubled among BRCA carriers in the 15-year period after the diagnosis of breast cancer (relative risk, 2.0; 95% confidence interval [CI], 1.4-2.8; P = .0001), compared with carriers without cancer. The risk was particularly high for women with a body mass index (BMI) >25.0 kg/m(2) (odds ratio, 5.8; 95% CI, 4.0-8.6; P = .0001). CONCLUSIONS:: After a diagnosis of breast cancer, women with a BRCA1 or BRCA2 mutation face a 2-fold increase in the risk of diabetes, which is exacerbated by a high BMI.

Citation Information
Louise Bordeleau, Lorraine Lipscombe, Jan Lubinski, Parviz Ghadirian, et al.. "Diabetes and Breast Cancer among Women with BRCA1 and BRCA2 Mutations" Cancer (2011)
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