Skip to main content
profile image
Selected Works of Peter Ainsworth
Article
Alcohol Consumption and the Risk of Breast Cancer among BRCA1 and BRCA2 Mutation Carriers
The Breast
  • Jessica Dennis, University of Ottawa
  • Parviz Ghadirian, University of Ottawa
  • Julian Little, University of Ottawa
  • Jan Lubinski, Pomeranian Medical University, Szczecin, Poland
  • Jacek Gronwald, Pomeranian Medical University, Szczecin, Poland
  • Charmaine Kim-Sing, BC Cancer Agency, Vancouver, BC
  • William Foulkes, McGill University
  • Pal Moller, The National Hospital, Oslo, Norway
  • Henry T. Lynch, Creighton University
  • Susan L. Neuhausen, University of California - Irvine
  • Susan Domchek, University of California - Irvine
  • Susan Armel, University Health Network, Toronto, ON
  • Claudine Isaacs, Georgetown University
  • Nadine Tung, Beth Israel Deaconess Hospital, Boston, MA
  • Kevin Sweet, Ohio State Medical Center
  • Peter Ainsworth, The University of Western Ontario
  • Ping Sun, University of Toronto
  • Daniel Krewski, University of Ottawa
  • Steven Narod, University of Toronto
  • Hereditary Breast Cancer Clinical Study Group, Hereditary Breast Cancer Clinical Study Group
Link Find in your library
Document Type
Article
Publication Date
12-1-2010
URL with Digital Object Identifier
http://dx.doi.org/10.1016/j.breast.2010.05.009
Disciplines
Abstract

Alcohol consumption increases the risk of breast cancer among women in the general population, but its effect on women who carry a BRCA gene mutation is unclear. We conducted a case-control study of 1925 matched pairs of predominantly premenopausal women who carry a BRCA1 or a BRCA2 mutation. Information on current alcohol consumption was obtained from a questionnaire administered during the course of genetic counselling or at the time of enrolment. A modest inverse association between breast cancer and reported current alcohol consumption was observed among women with a BRCA1 mutation (OR = 0.82, 95% CI 0.70-0.96), but not among women with a BRCA2 mutation (OR = 1.00; 95% CI 0.71-1.41). Compared to non-drinkers, exclusive consumption of wine was associated with a significant reduction in the risk of breast cancer among BRCA1 carriers (p-trend = 0.01). Alcohol consumption does not appear to increase breast cancer risk in women carrying a BRCA gene mutation.

Citation Information
Jessica Dennis, Parviz Ghadirian, Julian Little, Jan Lubinski, et al.. "Alcohol Consumption and the Risk of Breast Cancer among BRCA1 and BRCA2 Mutation Carriers" The Breast Vol. 19 Iss. 6 (2010) p. 479 - 483
Available at: http://works.bepress.com/peter-ainsworth/10/