"Synthesis of the C1–C23 Fragment of the Archazolids and Evidence for V-ATPase but not COX Inhibitory Activity" by Gregory W. O’Neil

Selected Works of P. Clint Spiegel

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Synthesis of the C1–C23 Fragment of the Archazolids and Evidence for V-ATPase but not COX Inhibitory Activity

Synlett (2017)

Gregory W. O’Neil, Western Washington University
Alexander M. Craig, Western Washington University
John R. Williams, Western Washington University
Jeffrey C. Young, Western Washington University
P. Clint Spiegel, Western Washington University

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Abstract

A convergent synthesis of a C₁–C₂₃ fragment of the archazolids has been completed based on a high-yielding Stille coupling to construct the substituted Z,Z,E-conjugated triene. After removal of the protecting groups, the resulting tetrol exhibited evidence for inhibition of the vacuolar-type ATPase (V-ATPase) but not cyclooxygenase (COX) inhibitory activity.

Keywords

archazolid,
natural product,
Stille reaction,
V-ATPase,
cyclooxygenase,
total synthesis

Disciplines

Publication Date

February 8, 2017

DOI

10.1055/s-0036-1588413

Publisher Statement

Published by Thieme

Citation Information

Gregory W. O’Neil, Alexander M. Craig, John R. Williams, Jeffrey C. Young, et al.. "Synthesis of the C1–C23 Fragment of the Archazolids and Evidence for V-ATPase but not COX Inhibitory Activity" Synlett Vol. 28 Iss. 9 (2017) p. 1101 - 1105
Available at: http://works.bepress.com/pc_spiegel/17/