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The risk of cancer in people with diabetes and chronic kidney disease
Nephrology Dialysis Transplantation
  • Germaine Wong, The Children's Hospital at Westmead, Sydney, Australia
  • Sophia Zoungas, University of Sydney
  • Serigne Lo, University of Sydney
  • John Chalmers, University of Sydney
  • Alan Cass, University of Sydney
  • Bruce Neal, University of Sydney
  • Mark Woodward, University of Sydney
  • Vlado Perkovic, University of Sydney
  • Paul P. Glasziou, Bond University
  • Bryan Williams, University of Leicester
  • Kirsten Howard, University of Sydney
  • Jeremy R Chapman, Westmead Hospital, Sydney, Australia
  • Jonathon C Craig, The Children's Hospital at Westmead, Sydney, Australia
Date of this Version
2-21-2012
Document Type
Journal Article
Publication Details

Citation only

Wong, G., Zoungas, S., Lo, S., Chalmers, J., Cass, A., Neal, B., Woodward, M., Perkovic, V., Glasziou, P., Williams, B., Howard, K., Chapman, J.R., & Craig, J.C. (2012). The risk of cancer in people with diabetes and chronic kidney disease. Nephrology Dialysis Transplantation, 27(8), 3337-3344

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2012 HERDC submission. FoR code: 111717; 110399

© Copyright The Authors, 2012

Abstract
Background: Diabetes and chronic kidney disease (CKD) are both associated with an increased risk of cancer but it is unclear whether diabetes complicated by CKD further augments an individual's cancer risk. The aim of our study was to determine the association of CKD [defined as an estimated glomerular filtration rate (eGFR) < 60 mL/min] with the overall and site-specific risks of incident cancers among individuals with Type 2 diabetes. Methods: Cox proportional hazard regression models and competing risk analyses were used to examine the univariate and multivariate adjusted associations between reduced kidney function and the overall and site-specific risks of cancer in participants enrolled in the Action in Diabetes and Vascular disease: Preterax and Diamicron MR controlled evaluation (ADVANCE) trial. Results: Over a median follow-up of 5.0 years, 700 malignant neoplasms occurred in the 11 140 (6.4%) participants. There was no increase in overall cancer risk [adjusted hazard ratio: 1.07 (95% confidence interval: 0.89–1.29, P = 0.50)] or site-specific cancer risk for individuals with CKD (defined as eGFR < 60 mL/min) compared to those without CKD at baseline. These results were robust to multiple methods and thresholds used to estimate CKD. Conclusions: Mild to moderate CKD does not increase the risk of cancer in people with Type 2 diabetes.
Citation Information
Germaine Wong, Sophia Zoungas, Serigne Lo, John Chalmers, et al.. "The risk of cancer in people with diabetes and chronic kidney disease" Nephrology Dialysis Transplantation Vol. 27 Iss. 8 (2012) p. 3337 - 3344 ISSN: 1460-2385
Available at: http://works.bepress.com/paul_glasziou/77/