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Taking healthcare interventions from trial to practice
BMJ (2010)
  • Paul Glasziou, University of Oxford
  • Iain Chalmers
  • Douglas G. Altman
  • Hilda Bastian
  • Isabelle Boutron
  • Anne Brice, University of Oxford
  • Gro Jamtvedt
  • Andrew Farmer, University of Oxford
  • Davina Ghersi
  • Trish Groves
  • Carl Heneghan, University of Oxford
  • Sophie Hill, La Trobe University
  • Simon Lewin
  • Susan Michie, University College London
  • Rafael Perera, University of Oxford
  • Valerie Pomeroy, University of East Anglia
  • Julie Tilson, University of Southern California
  • Sasha Shepperd, University of Oxford
  • John W. Williams

The results of thousands of trials are never acted on because their published reports do not describe the interventions in enough detail. How can we improve the reporting?

Much healthcare research is currently wasted because its findings are unusable.¹ Published reports of intervention trials often focus on the results and fail to describe interventions adequately. For example, a review of 80 studies selected for the journal Evidence Based Medicine as both valid and important for clinical practice found that clinicians could replicate the intervention in only half the studies.² Interventions may be used incorrectly or not at all if there is inadequate detail in the trial protocol, on the conduct of the trial, in systematic reviews and guidelines, and finally during implementation (fig 1⇓). This is an unnecessary but remediable waste, as we discuss below.

  • healthcare,
  • interventions,
  • trial,
  • practice
Publication Date
August 13, 2010
Publisher Statement
Published Version.

Glasziou, P., Chalmers, I., Altman, D. G., Bastian, H., Boutron, I., Brice, A., Jamtvedt, G., Farmer, A., Ghersi, D., Groves, T., Heneghan, C., Hill, S., Lewin, S., Michie, S., Perera, R., Pomeroy, V., Tilson, J., Shepperd, S., & Williams, J. W. (2010). Taking healthcare interventions from trial to practice. BMJ, 341(c3852 ), 384-387.

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© Copyright BMJ Publishing Group Ltd.
Citation Information
Paul Glasziou, Iain Chalmers, Douglas G. Altman, Hilda Bastian, et al.. "Taking healthcare interventions from trial to practice" BMJ Vol. 341 Iss. c3852 (2010)
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