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Article
New treatments compared to established treatments in randomized trials
Cochrane Database of Systematic Reviews
  • Benjamin Djulbegovic, University of South Florida
  • Ambuj Kumar, USF
  • Paul Glasziou, Bond University
  • Rafael Perera, University of Oxford
  • Tea Reljic, University of Oxford
  • Louise Dent, Southampton General Hospital
  • James Raftery, University of Southampton
  • Marit Johansen, Norwegian Knowledge for Health Services
  • Gian Luca Di Tanna, Sapienza University of Rome
  • Branko Miladinovic, USF
  • Heloisa Soares, Mount Sinai Medical Center
  • Gunn E Vist, Norwegian Knowledge Centre for the Health Services
  • Iain Chalmers, James Lind Library
Date of this Version
1-1-2012
Document Type
Journal Article
Publication Details

Citation only

Djulbegovic, B., Kumar, A., Glasziou, P. P., Perera, R., Reljic, T., Dent, L., Raftery, J., Johansen, M., Di Tanna, G.L, Miladinovic, B., Soares, H., Visit, G. & Chalmers, I. (2012). New treatments compared to established treatments in randomized trials. Cochrane Database of Systematic Reviews (Online), 10.

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© Copyright, The Cochrane Collaboration, 2012

NHMRC Project Grant GNT0527500

Abstract
BACKGROUND: The proportion of proposed new treatments that are 'successful' is of ethical, scientific, and public importance. We investigated how often new, experimental treatments evaluated in randomized controlled trials (RCTs) are superior to established treatments. OBJECTIVES: Our main question was: "On average how often are new treatments more effective, equally effective or less effective than established treatments?" Additionally, we wanted to explain the observed results, i.e. whether the observed distribution of outcomes is consistent with the 'uncertainty requirement' for enrollment in RCTs. We also investigated the effect of choice of comparator (active versus no treatment/placebo) on the observed results.
Citation Information
Benjamin Djulbegovic, Ambuj Kumar, Paul Glasziou, Rafael Perera, et al.. "New treatments compared to established treatments in randomized trials" Cochrane Database of Systematic Reviews (2012) ISSN: 1469-493X
Available at: http://works.bepress.com/paul_glasziou/127/