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Article
Effects of visit-to-visit variability in systolic blood pressure on macro vascular and micro vascular complications in patients with type 2 diabetes mellitus: The advance trial
Circulation
  • Jun Hata, University of Sydney
  • Hisatomi Arima, University of Sydney
  • Peter Rothwell, University of Oxford
  • Mark Woodward, University of Sydney
  • Sophia Zoungas, University of Sydney
  • Craig Anderson, University of Sydney
  • Anushka Patel, University of Sydney
  • Bruce Neal, University of Sydney
  • Paul Glasziou, Bond University
  • Pavel Hamet, University of Montreal
  • Giuseppe Mancia, University of Milano-Bicocca
  • Neil Poulter, Imperial College London
  • Bryan Williams, University College of London
  • Stephen MacMahon, University of Sydney
  • John Chalmers, University of Sydney
Date of this Version
9-17-2013
Document Type
Journal Article
Publication Details

Citation only

Hata, J., Arima, H., Rothwell, P. M., Woodward, M., Zoungas, S., Anderson, C.,Patel, A., Neal, B., Glasziou, P., Hamet, P., Macia, G., Poulter, N., Williams, B., MacMahon, S., & Chalmers, J. (2013). Effects of visit-to-visit variability in systolic blood pressure on macro vascular and micro vascular complications in patients with type 2 diabetes mellitus: The advance trial. Circulation, 128(12), 1325-1334.

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© Copyright, American Heart Association, 2013

2013 HERDC submission. FoR Code: 111717;110399

NHMRC Project Grant 0527500

Abstract
Recent evidence suggests that visit-to-visit variability in systolic blood pressure (SBP) and maximum SBP are predictors of cardiovascular disease. However, it remains uncertain whether these parameters predict the risks of macro vascular and micro vascular complications in patients with type 2 diabetes mellitus. METHODS AND RESULTS-: The Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) was a factorial randomized controlled trial of blood pressure lowering and blood glucose control in patients with type 2 diabetes mellitus. The present analysis included 8811 patients without major macrovascular and microvascular events or death during the first 24 months after randomization. SBP variability (defined as standard deviation) and maximum SBP were determined during the first 24 months after randomization. During a median 2.4 years of follow-up from the 24-month visit, 407 major macrovascular (myocardial infarction, stroke, or cardiovascular death) and 476 microvascular (new or worsening nephropathy or retinopathy) events were observed. The association of major macrovascular and microvascular events with SBP variability was continuous even after adjustment for mean SBP and other confounding factors (both P
Citation Information
Jun Hata, Hisatomi Arima, Peter Rothwell, Mark Woodward, et al.. "Effects of visit-to-visit variability in systolic blood pressure on macro vascular and micro vascular complications in patients with type 2 diabetes mellitus: The advance trial" Circulation (2013) ISSN: 0009-7322
Available at: http://works.bepress.com/paul_glasziou/106/