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Article
LuxS and Quorum-Sensing in Campylobacter
Frontiers in Cellular and Infection Microbiology
  • Paul J. Plummer, Iowa State University
Document Type
Article
Publication Version
Published Version
Publication Date
3-1-2012
DOI
10.3389/fcimb.2012.00022
Abstract
Several intercellular bacterial communication mechanisms have been identified in a broad range of bacterial species. These systems, collectively termed quorum-sensing systems, have been demonstrated to play significant roles in a variety of bacterial processes including motility, biofilm formation, expression of virulence genes, and animal colonization. Campylobacter jejuni is known to possess a LuxS/ autoinducer-2 (AI-2) mediated system that have been partially characterized over the last decade. AI-2 is formed as a byproduct of the activated methyl recycling pathway, specifically by the LuxS enzyme. Previous work in our laboratory and that of others has demonstrated that this gene is involved in a variety of physiologic pathways of C. jejuni including motility, autoagglutination, cytolethal distending toxin (CDT) expression, flagellar expression, oxidative stress, and animal colonization. This review article will summarize the current research associated with LuxS in C. jejuni and will provide insights into the role of this system in the metabolism and intercellular communication of this organism. Additionally, the evidence for other quorum-sensing pathways in Campylobacter will be discussed.
Comments

This article is from Frontiers in Cellular and Infection Microbiology 2 (2012): 22, doi:10.3389/fcimb.2012.00022. Posted with permission.

Rights
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Copyright Owner
Paul J. Plummer
Language
en
File Format
application/pdf
Citation Information
Paul J. Plummer. "LuxS and Quorum-Sensing in Campylobacter" Frontiers in Cellular and Infection Microbiology Vol. 2 (2012) p. 1 - 9
Available at: http://works.bepress.com/paul-plummer/9/