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Patrick Flaherty
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University of Massachusetts Amherst
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Research Works
Research Works
(13)
Article
Identification of a new class of antifungals targeting the synthesis ...
mBio (2015)
Patrick Flaherty
Recent estimates suggest that>300 million people are afflicted by serious fungal infections worldwide. Current antifungal drugs are static and toxic ...
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Article
RVD2: an ultra-sensitive variant detection model for low-depth heterogeneous next-generation ...
Bioinformatics (2015)
Patrick Flaherty
MOTIVATION:Next-generation sequencing technology is increasingly being used for clinical diagnostic tests. Clinical samples are often genomically heterogeneous due to low ...
Link
Article
GLAD: A mixed-membership model for heterogeneous tumor subtype classification
Bioinformatics (2014)
Patrick Flaherty
MOTIVATION:Genomic analyses of many solid cancers have demonstrated extensive genetic heterogeneity between as well as within individual tumors. However, statistical ...
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Article
Metastatic Tumor Evolution in Diuse Gastric Cancer and Cancer ...
Genome Biology (2014)
Patrick Flaherty
Background: Gastric cancer is the second-leading cause of global cancer deaths, with metastatic disease representing the primary cause of mortality. ...
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Article
Prediction of Multiple Infections After Severe Burn Trauma: a Prospective ...
Annals of Surgery (2014)
Patrick Flaherty
OBJECTIVE:To develop predictive models for early triage of burn patients based on hypersusceptibility to repeated infections.BACKGROUND:Infection remains a major cause ...
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Article
Systematic genomic identification of colorectal cancer genes delineating advanced from ...
BMC Medical Genomics (2013)
Patrick Flaherty
Background: Colorectal cancer is the third leading cause of cancer deaths in the United States. The initial assessment of colorectal ...
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Article
RVD: A command-line program for ultrasensitive rare single nucleotide variant ...
BMC Research Notes (2013)
Patrick Flaherty
Background: Rare single nucleotide variants play an important role in genetic diversity and heterogeneity of specific human disease. For example, ...
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Article
Ultrasensitive Detection of Rare Mutations using Next-Generation Targeted Resequencing
Nucleic Acids Research (2011)
Patrick Flaherty
With next-generation DNA sequencing technologies, one can interrogate a specific genomic region of interest at very high depth of coverage ...
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Article
A Dual Receptor Cross-talk Model of G protein-coupled Signal Transduction ...
PLOS Computational Biology (2008)
Patrick Flaherty
Link
Article
A latent Variable Model for Chemogenomic Profiling
Bioinformatics (2005)
Patrick Flaherty
Motivation: In haploinsufficiency profiling data, pleiotropic genesare often misclassified by clustering algorithms that impose the constraint that a gene or ...
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Article
Genome-Wide Requirements for Resistance to Functionally Distinct DNA-Damaging Agents
PLOS Genetics (2005)
Patrick Flaherty
The mechanistic and therapeutic differences in the cellular response to DNA-damaging compounds are not completely understood, despite intense study. To ...
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Article
Chemogenomic profiling: Identifying the functional interactions of small molecules in ...
Proceedings of the National Academy of Sciences (2004)
Patrick Flaherty
We demonstrate the efficacy of a genome-wide protocol in yeastthat allows the identification of those gene products that functionallyinteract with ...
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Article
Functional Profiling of the Saccharomyces cerevisiae Genome
Nature (2002)
Patrick Flaherty
Determining the effect of gene deletion is a fundamental approach to understanding gene function. Conventional genetic screens exhibit biases, and ...
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