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Feasibility and Compliance with Daily Home ECG Monitoring of the QT Interval in Heart Transplant Recipients
Heart Lung
  • Erik V. Carter, University of California, San Francisco School of Nursing, San Francisco
  • Kathleen T. Hickey, Columbia University School of Nursing, NYC
  • David M. Pickham, University of California, San Francisco School of Nursing, San Francisco
  • Lynn V. Doering, University of California, Los Angeles School of Nursing, Los Angeles
  • Belinda Chen, University of California, Los Angeles School of Nursing, Los Angeles
  • Patricia R. E. Harris, University of California, San Francisco School of Nursing, San Francisco
  • Barbara J. Drew, University of California, San Francisco School of Nursing, San Francisco
Document Type
Article
Publication Date
1-1-2012
Department
Nursing
Abstract

About 13% of adult heart transplant recipients do not survive to one year and a major cause of death is acute cellular allograft rejection.1,2 According to the 2009 annual United States data published from the International Society for Heart Lung Transplantation Registry, acute rejection occurs in 25 – 35% of transplant recipients within the first year following transplant surgery.3 In order to detect the early stages of rejection so that more aggressive and early immunosuppressant therapy can be initiated, frequent biopsies of heart tissue are performed (typically, weekly or every other week in the first 3 months and then monthly or every other month during the first year). Although endomyocardial biopsy (EMB) is not a perfect “gold standard” for a correct diagnosis of acute allograft rejection, it is considered the best available test and thus, it is the current standard practice. Unfortunately, EMB is an invasive and costly procedure that is not without risk.4,5 If a simple noninvasive biomarker could be identified to detect the early stages of acute rejection, it might be possible to reduce the number of invasive biopsy procedures and to initiate earlier therapy that might prevent death from severe rejection.

Rights

Copyright © 2012 Elsevier. All rights reserved.

Publisher Statement
Originally published as Carter, E. V., Hickey, K. T., Pickham, D. M., Doering, L. V., Chen, B., Harris, P. R., & Drew, B. J. (2012). Feasibility and compliance with daily home electrocardiogram monitoring of the QT interval in heart transplant recipients. Heart & Lung: The Journal of Acute and Critical Care, 41(4), 368-373.
Citation Information
Erik V. Carter, Kathleen T. Hickey, David M. Pickham, Lynn V. Doering, et al.. "Feasibility and Compliance with Daily Home ECG Monitoring of the QT Interval in Heart Transplant Recipients" Heart Lung Vol. 41 Iss. 4 (2012) p. 368 - 373 ISSN: 0147-9563
Available at: http://works.bepress.com/patricia_harris/49/