Skip to main content
Article
Heart Rate Variability Measured Early in Patients with Evolving Acute Coronary Syndrome and 1-year Outcomes of Rehospitalization and Mortality
Vascular Health and Risk Management
  • Patricia R.E. Harris, Electrocardiographic Monitoring Research Laboratory, School of Nursing, Department of Physiological Nursing, University of California
  • Phyllis K. Stein, Heart Rate Variability Laboratory, School of Medicine, Division of Cardiology, Washington University
  • Gordon L. Fung, Cardiology Services, Mount Zion, Department of Medicine, Division of Cardiology, University of California, San Francisco
  • Barbara J. Drew, School of Nursing, Department of Physiological Nursing, Division of Cardiology, University of California, San Francisco
Document Type
Article
Publication Date
8-1-2014
Abstract
Objective: This study sought to examine the prognostic value of heart rate variability (HRV) measurement initiated immediately after emergency department presentation for patients with acute coronary syndrome (ACS). Background: Altered HRV has been associated with adverse outcomes in heart disease, but the value of HRV measured during the earliest phases of ACS related to risk of 1-year rehospitalization and death has not been established. Methods: Twenty-four-hour Holter recordings of 279 patients with ACS were initiated within 45 minutes of emergency department arrival; recordings with �18 hours of sinus rhythm were selected for HRV analysis (number [N] �193). Time domain, frequency domain, and nonlinear HRV were examined. Survival analysis was performed. Results: During the 1-year follow-up, 94 patients were event-free, 82 were readmitted, and 17 died. HRV was altered in relation to outcomes. Predictors of rehospitalization included increased normalized high frequency power, decreased normalized low frequency power, and decreased low/high frequency ratio. Normalized high frequency �42 ms2 predicted rehospitalization while controlling for clinical variables (hazard ratio [HR] �2.3; 95% confidence interval [CI] �1.4–3.8, P�0.001). Variables significantly associated with death included natural logs of total power and ultra low frequency power. A model with ultra low frequency power �8 ms2 ( HR �3.8; 95% CI �1.5–10.1; P�0.007) and troponin �0.3 ng/mL (HR �4.0; 95% CI �1.3–12.1; P�0.016) revealed that each contributed independently in predicting mortality. Nonlinear HRV variables were significant predictors of both outcomes. Conclusion: HRV measured close to the ACS onset may assist in risk stratification. HRV cut-points may provide additional, incremental prognostic information to established assessment guidelines, and may be worthy of additional study.
Publisher Statement
Originally published as: Harris PR, Stein PK, Fung GL, Drew BJ. (2014). Heart rate variability measured early in patients with evolving acute coronary syndrome and one-year outcomes of rehospitalization. Vascular Health Risk Management, 10.451-64. Dove Medical Press.
Creative Commons License
Creative Commons Attribution-Noncommercial 4.0
Citation Information
Patricia R.E. Harris, Phyllis K. Stein, Gordon L. Fung and Barbara J. Drew. "Heart Rate Variability Measured Early in Patients with Evolving Acute Coronary Syndrome and 1-year Outcomes of Rehospitalization and Mortality" Vascular Health and Risk Management Vol. 10 (2014) p. 451 - 464 ISSN: 1178-2048
Available at: http://works.bepress.com/patricia_harris/43/