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Article
Platelet Satellitism and Dual Surface Immunoglobulin Light-Chain Expression in Circulating Splenic Marginal Zone Lymphoma Cells
Annals of Diagnostic Pathology
  • Naomi Montague, University of Miami
  • Patricia Blackwelder, University of Miami
  • Husain Ala Al Sayegh, University of Miami
  • Roberto Ochoa, University of Miami
  • Ximena Vial, University of Miami
  • Gerald E. Byrne, University of Miami
Document Type
Article
Publication Date
2-1-2013
Keywords
  • Satellitism,
  • Flow cytometry,
  • Lymphoma,
  • Dual light chain expression,
  • Transmission electron microscopy (TEM),
  • Scanning electron microscopy (SEM)
Peer Reviewed
1
Abstract
Platelet satellitism is believed to be an in vitro phenomenon induced at room temperature in ethylenediamine tetraacetic acid–anticoagulated blood. Most reports involve neutrophils; involvement with circulating lymphoma cells are exceedingly rare. Normally, mature B cells exhibit allelic exclusion in which a single class of surface immunoglobulin light chains (either κ or λ ) is expressed. The simultaneous expression of both κ and λ immunoglobulin light chains is rare. Herein, we report the unusual case of a patient with splenic marginal zone lymphoma in which circulating lymphoma cells express dual surface immunoglobulin light chains and exhibit platelet satellitism. In addition to clinical findings, a comprehensive analysis of the peripheral blood including correlated light and electron microscopy as well as flow cytometry are described.
Comments

©2013 Elsevier Inc.

DOI
10.1016/j.anndiagpath.2011.06.001
Citation Information
Naomi Montague, Patricia Blackwelder, Husain Ala Al Sayegh, Roberto Ochoa, et al.. "Platelet Satellitism and Dual Surface Immunoglobulin Light-Chain Expression in Circulating Splenic Marginal Zone Lymphoma Cells" Annals of Diagnostic Pathology Vol. 17 Iss. 1 (2013) p. 117 - 122 ISSN: 1092-9134
Available at: http://works.bepress.com/patricia-blackwelder/27/