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Article
Lens Regeneration in Axolotl: New Evidence of Developmental Plasticity
BMC Biology
  • Rinako Suetsugu-Maki
  • Nobuyasu Maki
  • Saulius Sumanas
  • Jie Zhu
  • Katia Del Rio-Tsonis
  • Panagiotis A. Tsonis, University of Dayton
Document Type
Article
Publication Date
1-1-2012
Abstract

Background: Among vertebrates lens regeneration is most pronounced in newts, which have the ability to regenerate the entire lens throughout their lives. Regeneration occurs from the dorsal iris by transdifferentiation of the pigment epithelial cells. Interestingly, the ventral iris never contributes to regeneration. Frogs have limited lens regeneration capacity elicited from the cornea during pre-metamorphic stages. The axolotl is another salamander which, like the newt, regenerates its limbs or its tail with the spinal cord, but up until now all reports have shown that it does not regenerate the lens.

ISBN/ISSN
1741-7007
Document Version
Published Version
Publisher
BioMed Central
Peer Reviewed
Yes
Keywords
  • Biomed Central Ltd,
  • Article,
  • Iris
Disciplines
Citation Information
Rinako Suetsugu-Maki, Nobuyasu Maki, Saulius Sumanas, Jie Zhu, et al.. "Lens Regeneration in Axolotl: New Evidence of Developmental Plasticity" BMC Biology Vol. 10 Iss. 103 (2012)
Available at: http://works.bepress.com/panagiotis_tsonis/13/