Students with significant disabilities are most at risk for exclusion from grade-aligned content due to the barriers imposed by traditional instruction. This presentation will provide special and general education teachers with effective, research-based strategies to increase comprehension in content areas, including math, science, ELA, and social studies. Learner outcomes: • Participants will learn about research-based strategies to increase comprehension in content areas, including math, science, ELA, and social studies; • Participants will learn about results from a recent review of the literature focused on comprehension strategies targeting Common Core content areas for students with Autism Spectrum Disorder and Intellectual Disability; and • Participants will be provided with specific comprehension strategies and ways to increase opportunities for comprehension in inclusive contexts for students across a variety of diverse backgrounds.