The association of early life supplemental nutrition with lean body mass and grip strength in adulthood: Evidence from APCAPSAmerican Journal of Epidemiology (2014)
AbstractIn the present study, we examined the associations of early nutrition with adult lean body mass (LBM) and muscle strength in a birth cohort that was established to assess the long-term impact of a nutrition program. Participants (n = 1,446, 32% female) were born near Hyderabad, India, in 29 villages from 1987 to 1990, during which time only intervention villages (n = 15) had a government program that offered balanced protein-calorie supplementation to pregnant women and children. Participants’ LBM and appendicular skeletal muscle mass were measured using dual energy x-ray absorptiometry; grip strength and information on lifestyle indicators, including diet and physical activity level, were also obtained. Ages (mean = 20.3 years) and body mass indexes (weight (kg)/height (m)2; mean = 19.5) of participants in 2 groups were similar. Current dietary energy intake was higher in the intervention group. Unadjusted LBM and grip strength were similar in 2 groups. After adjustment for potential confounders, the intervention group had lower LBM (β = −0.75; P = 0.03), appendicular skeletal muscle mass, and grip strength than did controls, but these differences were small in magnitude (<0.1 standard deviation). Multivariable regression analyses showed that current socioeconomic position, energy intake, and physical activity level had a positive association with adult LBM and muscle strength. This study could not detect a “programming” effect of early nutrition supplementation on adult LBM and muscle strength.
- dual energy
Publication DateFebruary 19, 2014
Citation InformationBharati Kulkarni, Hannah Kuper, K Radhakrishna, Andrew Hills, et al.. "The association of early life supplemental nutrition with lean body mass and grip strength in adulthood: Evidence from APCAPS" American Journal of Epidemiology Vol. 179 Iss. 6 (2014)
Available at: http://works.bepress.com/nuala_byrne/25/