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The association of early life supplemental nutrition with lean body mass and grip strength in adulthood: Evidence from APCAPS
American Journal of Epidemiology (2014)
  • Bharati Kulkarni
  • Hannah Kuper
  • K Radhakrishna
  • Andrew Hills, Griffith University
  • Nuala Byrne, Queensland University of Technology
  • Amy Taylor, University of Bristol
  • Ruth Sullivan
  • Liza Bowen
  • Jonathan Wells
  • Yoav Ben-Shlomo, University of Bristol
  • George Davey-Smith, University of Bristol
  • Shah Ebrahim
  • Sanjay Kinra
Abstract
In the present study, we examined the associations of early nutrition with adult lean body mass (LBM) and muscle strength in a birth cohort that was established to assess the long-term impact of a nutrition program. Participants (n = 1,446, 32% female) were born near Hyderabad, India, in 29 villages from 1987 to 1990, during which time only intervention villages (n = 15) had a government program that offered balanced protein-calorie supplementation to pregnant women and children. Participants’ LBM and appendicular skeletal muscle mass were measured using dual energy x-ray absorptiometry; grip strength and information on lifestyle indicators, including diet and physical activity level, were also obtained. Ages (mean = 20.3 years) and body mass indexes (weight (kg)/height (m)2; mean = 19.5) of participants in 2 groups were similar. Current dietary energy intake was higher in the intervention group. Unadjusted LBM and grip strength were similar in 2 groups. After adjustment for potential confounders, the intervention group had lower LBM (β = −0.75; P = 0.03), appendicular skeletal muscle mass, and grip strength than did controls, but these differences were small in magnitude (<0.1 standard deviation). Multivariable regression analyses showed that current socioeconomic position, energy intake, and physical activity level had a positive association with adult LBM and muscle strength. This study could not detect a “programming” effect of early nutrition supplementation on adult LBM and muscle strength.
Keywords
  • ASM,
  • appendicular,
  • skeletal,
  • mass,
  • DXA,
  • dual energy
Publication Date
February 19, 2014
Publisher Statement
This work is licensed under a Creative Commons 3.0 Licence http://creativecommons.org/licenses/by/3.0/
Citation Information
Bharati Kulkarni, Hannah Kuper, K Radhakrishna, Andrew Hills, et al.. "The association of early life supplemental nutrition with lean body mass and grip strength in adulthood: Evidence from APCAPS" American Journal of Epidemiology Vol. 179 Iss. 6 (2014)
Available at: http://works.bepress.com/nuala_byrne/25/