Despite recent advances, limited treatment options remain for patients with advanced multiple myeloma. Francesca Gay, MD, and colleagues from the University of Torino, Italy, found that combination treatment using carfilzomib, bendamustine, and dexamethasone appears to be an effective treatment in the outpatient setting for this patient population. However, they cautioned, infection prophylaxis and attention to those with cardiovascular predisposition are necessary. Their results were published in the journal Cancer.