Recent research has identified a potential diagnostic and prognostic role for the intracellular enzyme paraoxonase-2 (PON2) in skin neoplasms, such as basal cell carcinoma. Tiziana Bacchetti, PhD, and colleagues from the Polytechnic University of Marche, Ancona, Italy, reported that PON2 expression levels seem to correlate with the aggressiveness of both basal cell cancer and melanoma. Their findings were published in the European Journal of Clinical Investigation.