We provide a semiquantitative tool, derived from first-principles simulations, for answering the question of whether certain types of defects in solid 4He support mass superflow. Although ideal crystals of 4He are not supersolid, the gap for vacancy creation closes when applying a moderate stress. While a homogeneous system becomes unstable at this point, the stressed core of crystalline defects (dislocations and grain boundaries) can turn superfluid.