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Article
Lipids, Lipoproteins, Lifestyle, Adiposity and Fat-Free Mass during Middle Age: The Fels Longitudinal Study
International Journal of Obesity
  • C. M. Schubert
  • Nikki Lynn Rogers, Wright State University - Main Campus
  • Karen E. Remsberg
  • Shumei S. Sun
  • William Cameron Chumlea, Wright State University - Main Campus
  • Ellen W. Demerath
  • Stefan A. Czerwinski, Wright State University - Main Campus
  • Bradford Towne, Wright State University - Main Campus
  • Roger M. Siervogel, Wright State University - Main Campus
Document Type
Article
Publication Date
2-1-2006
Abstract
Introduction: Although lipid profiles tend to worsen with age, it is not fully known if such age-related changes are influenced primarily by body composition and lifestyle or by other aspects of aging. Objective: We investigated the extent to which the fat and fat-free components of body mass index (BMI) and lifestyle factors influence patterns of change in lipids independent of age. Design: Serial data were analyzed using sex-specific longitudinal models. These models use serial data from individuals to assume a general pattern of change over time, while allowing baseline age and the rate of change to vary among individuals. Subjects: Serial data were obtained from 940 examinations of 269 healthy white participants (126 men, 143 women), aged 40–60 years, in the Fels Longitudinal Study. Measurements: Measurements included age, the fat (FMI) and fat-free mass (FFMI) components of BMI, high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), triglycerides (TG), total cholesterol (TC), fasting glucose and insulin, physical activity, alcohol use and smoking, and women's menopausal status and estrogen use. Results: In both sexes, increased FMI was significantly associated with increased LDL-C, TG and TC, and decreased HDL-C. Increased FFMI was significantly related to decreased HDL-C and increased TG. Independent age effects remained significant only for LDL-C and TC in men and TC in women. Increased insulin was significantly related to increased TG in women. Moderate alcohol consumption was associated with higher HDL-C in men. Physical activity lowered male LDL-C and TC levels, and increased female HDL-C levels. Menopause was associated with increases in LDL-C. Premenopausal women not using estrogen had significantly lower HDL-C, TG, and TC than postmenopausal women taking estrogen. Conclusions: (1) Age is an important independent predictor for LDL-C and TC in men, and TC in women, but it is not as influential as body composition and lifestyle on HDL-C and TG in men and women, and LDL-C in women. (2) Increasing FMI is the major contributor to elevated TC, LDL-C and TG levels, and decreased HDL-C levels in men and women. (3) FFMI significantly influences HDL and TG levels in both sexes. (4) Maintaining a lower BMI via a reduced fat component may be more beneficial in lowering CVD risks than other factors.
DOI
10.1038/sj.ijo.0803129
Citation Information
C. M. Schubert, Nikki Lynn Rogers, Karen E. Remsberg, Shumei S. Sun, et al.. "Lipids, Lipoproteins, Lifestyle, Adiposity and Fat-Free Mass during Middle Age: The Fels Longitudinal Study" International Journal of Obesity Vol. 30 Iss. 2 (2006) p. 251 - 260 ISSN: 03070565
Available at: http://works.bepress.com/nikki_rogers/35/