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In vitro cytotoxicity of new water soluble copper(II) metallates containing 7-hydroxy-4-oxo-4H-chromene thiosemicarbazones
Polyhedron (2019)
  • G. Kalaiarasi, Bharathiar University
  • S. Rex Jeya Rajkumar, Department of Biotechnology, Vignan's Foundation for Science, Technology and Research (Deemed to be University), Guntur 522 213, India
  • S. Dharani, Bharathiar University
  • Nigam P. Rath, University of Missouri–St. Louis
  • R. Prabhakaran, Bharathiar University
Abstract
7-Hydroxy-4-oxo-4H-chromene Schiff bases and their corresponding water soluble copper(II) complexes were synthesized and characterized by various spectral techniques. The structural confirmation of the complexes 2 and 3 has been provided by X-ray crystallographic analysis. The binding affinities of the ligands and complexes with Calf Thymus DNA (CT-DNA) and proteins (Bovine Serum Albumin (BSA) and Human Serum Albumin (HSA)) were studied by using absorption and emission titration methods. An intercalative mode of binding with CT-DNA and a static quenching mechanism with albumin (BSA and HSA) was confirmed from the obtained results. The efficiency of the compounds in inhibiting the microbial growth was tested against various pathogenic bacteria Pseudomonas aeruginosaStaphylococcus aureusStreptococcus pneumoniae and Acinetobacter baumannii by using Gentamicin as standard and fungi Candida albicansAspergillus nigerTrichophyton rubrumCandida tropicalis and Aspergillus fumigatus by using ketoconazole as standard and a significant activity has been found for the complexes. The anticancer potential of the ligands and complexes were tested against A549 and MCF-7 cells by MTT assay using cisplatin as a standard. The complexes 1–4 showed better cytotoxic profile than cisplatin, when incubated for a period of 48 h and 72 h. The results of all the biological analyses indicated the higher activity of the complexes over the ligands. Out of the complexes, complex 3 with the more electron donating ethyl group exhibited the higher activity.
Graphical abstract
Keywords
  • Copper(II) complexes,
  • Chromone Schiff bases,
  • DNA/protein binding,
  • Antimicrobial activity,
  • Anticancer ability
Disciplines
Publication Date
November 15, 2019
DOI
10.1016/J.POLY.2019.114120
Citation Information
G. Kalaiarasi, S. Rex Jeya Rajkumar, S. Dharani, Nigam P. Rath, et al.. "In vitro cytotoxicity of new water soluble copper(II) metallates containing 7-hydroxy-4-oxo-4H-chromene thiosemicarbazones" Polyhedron Vol. 173 (2019) p. 114120
Available at: http://works.bepress.com/nigam-rath/351/