Incorporation of chlorinated analogues of aliphatic amino acids during cell-free protein synthesisFaculty of Science - Papers (Archive)
Abstract3-Chloro-Abu and 4-chloro-Nva are biosynthetically incorporated into E. coli peptidyl-Pro cis-trans isomerase B, as substitutes for Val and Leu, respectively. The extent of incorporation is up to 90%, and substituted protein is catalytically active. By contrast, 4-chloro-Val is not an effective replacement for Ile.
Citation InformationDannon J. Stigers, Zachary I. Watts, James E. Hennessy, Hye-Kyung Kim, et al.. "Incorporation of chlorinated analogues of aliphatic amino acids during cell-free protein synthesis" (2011)
Available at: http://works.bepress.com/nick_dixon/60/